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The first 22 pairs of chromosomes (called autosomes) are numbered from 1 to 22, from largest to smallest.The 23rd pair of chromosomes are the sex chromosomes.Trisomy 18 and Trisomy 13, known as Edwards Syndrome and Patau Syndrome, respectively, are the two other autosomal trisomies recognized in live-born humans.Trisomy of the sex chromosomes is also possible, for example (47, XXX), (47, XXY), and (47, XYY).The most common aneuploidy that infants can survive with is trisomy 21, which is found in Down syndrome, affecting 1 in 800 births.Trisomy 18 (Edwards syndrome) affects 1 in 6,000 births, and trisomy 13 (Patau syndrome) affects 1 in 10,000 births.For organisms that normally have three or more copies of each chromosome (those that are triploid or above), disomy is an aneuploid chromosome complement.In uniparental disomy, both copies of a chromosome come from the same parent (with no contribution from the other parent).

(The sperm and egg, or gametes, each have 23 unpaired chromosomes, and red blood cells have no nucleus and no chromosomes.) One copy of each pair is inherited from the mother and the other copy is inherited from the father.Different species normally have different numbers of chromosomes from one another, and the terms aneuploid and polyploid refer to the chromosome number being different from the usual number for that species.Chromosome abnormalities are detected in 1 of 160 live human births.For many of the autosomal trisomies, only mosaic cases survive to term.However, mitotic aneuploidy may be more common than previously recognized in somatic tissues, and aneuploidy is a characteristic of many types of tumorigenesis (see below).

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  1. After she and her long-term boyfriend broke up, Marla decided to pursue the interests she had neglected when she was in a relationship. I made some wonderful friends and expanded my horizons.